Use at night time only. Cleanse your face and neck with Cleansing Cream. Snap open an ampoule at the neck (using a tissue or towel to protect your fingers), tap the contents into the palm of your hand and apply to face, neck and earlobes. Press in gently until it is absorbed. Use 1-2 ampoules each night. The ampoules work best if used nightly for 25 days, as they can then work eith the skin's own natural cycle to balance out any problems. However, a 5-day course may be used to give the skin a "boost".